Blood-Based Non-Invasive Tests of Hepatic Fibrosis in Autoimmune Hepatitis: Application among Selected Patients Leads to Higher Accuracy

Background. Assessment of liver fibrosis is essential to guide treatment in autoimmune hepatitis (AIH), but non-invasive tests (NITs) showed poor accuracy. Our study aims evaluate the performance NITs among different AIH presentations. Methods. Monocentric retrospective 122 patients. were compared histological grading fibrosis. We performed an accuracy analysis acute (jaundice and/or transaminases > 10 times upper limit normal) and non-acute Results. A significant difference distribution NIT values for each Ishak stage was found spleen-diameter-to-platelet-count ratio (SD/PC) (p < 0.001), fibrosis-4-score (FIB-4) = 0.002), AST-to-ALT (AAR) red-blood-cell-width-distribution-to-platelet-count (RDW/PC) 0.008) AST-to-platelet-count (APRI) 0.029). The AUC advanced SD/PC, FIB-4, RDW/PC, APRI AAR were, respectively, 0.814, 0.770, 0.768, 0.708 0.694. FIB-4 subgroup 0.902, 0.834 0.758, while patients they 0.754, 0.724 0.716. RDW/PC weren’t two subgroups. Conclusions. For APRI, diagnostic higher with presentation. In this context, SD/PC overall that could be interest clinical practice alongside other techniques.